3月3日,约翰·霍普金斯大学、华盛顿大会研究团队在《自然》(Nature)发表论文Genetically encoded assembly recorder temporally resolves cellular history,报告他们开发了一个细胞内记录平台GEMINI,该平台以AI计算设计的蛋白质组装体为核心记忆装置,通过活细胞内可预测的逐层生长,将细胞事件以类似树木年轮的荧光模式进行永久记录,可通过成像实现追溯性读取,对细胞活动历史的绝对时间解码精度达小时级,可分辨近15分钟的细胞动力学过程。
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,这一点在谷歌中也有详细论述
\nIn 2023, Pulendran’s team published a study in mice elucidating the mechanism. Like other vaccines, the tuberculosis vaccine induced both an innate and adaptive immune response in the mice, but unusually, the innate response was sustained for several months. The researchers discovered that T cells recruited to the lungs as part of the adaptive response were sending signals to the innate immune cells to keep them active.
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